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Pharmacotherapeutic group: Topical Anti-Inflammatory/Anti-Rheumatic.
Pharmacology: Uniren Spray 1% w/w is an anti-inflammatory and analgesic preparation designed for external application.
Pharmacokinetics: After cutaneous application of 1.5 g of Uniren Spray 1% w/w, a rapid onset of Diclofenac absorption can be observed leading to measurable plasma levels of about 1 ng/mL as early as 30 minutes and to maximum levels of about 3 ng/mL at about 24 hours after application.
The achieved systemic concentrations of Diclofenac are about 50 times lower than those achieved following oral administration of equivalent amounts of Diclofenac. Systemic plasma levels are not supposed to contribute to the efficacy of Uniren Spray 1% w/w.
Diclofenac is extensively bound to plasma proteins (about 99%).
